Munchkin Game Changers collects the cards from four out-of-print Munchkin boosters (Munchkin Fairy Dust, Munchkin Monster Enhancers, Munchkin Reloaded!, and Munchkinomicon), along with the cards from Munchkin Fairy Dust Dice and four cards previously available only directly from Steve Jackson Games. (The total card count is 68.) This set also contains two unique Munchkin Level Counters – one for Fairy Dust and the other for Munchkinomicon – as well as two 19mm sparkly pink dice. The four individual cards not previously distributed to outside markets are:

"Bull-Headed" (from the 2011 Exclusive Warehouse 23 Munchkin Booster)
"Fairy Dust-Up" (from Munchkin Promo Cards)
"Pumped-Up" (from the 2011 Exclusive Warehouse 23 Munchkin Booster)
"Reload!" (from the 2010 Exclusive Warehouse 23 Munchkin Booster)

Munchkin Game Changers was available exclusively from the Barnes & Noble bookstore chain until November 2014, when it is announced to enter the normal distribution market.