The great Pharaoh Mino has passed, and rule passes to his eldest son: Pharoah Mido. Displeased with the plain appearance of the pyramid in which his father was buried, Mido turns his attention to his own legacy. He wishes for his own resting place to better reflect his majesty and has decreed that 2-4 architects build pyramids encrusted with jewels: a pyramido. The architect who builds the most impressive pyramido will be appointed Vizier and enjoy wealth and power beyond imagination.

Pyramido is a tile-placement game in which each stage of the pyramid creates connections between them. Players take turns choosing from the available dominoes to create their pyramid. To maximize their points, players must match the jewel icons on the dominoes and place their markers of the same colors to activate the scoring areas. Each choice of domino and its positioning has a significant impact since the previous stages influence the score throughout the game.